![]() ![]() At baseline, OSA status will be assessed by home sleep polygraphy (HSP), and CPAP will be adopted according to national guidelines. All of them will be followed up in 4 visits: baseline, 6 months prior to BS and 3, 6 and 12 months post-BS. ![]() Three groups will be formed: MO without OSA, MO with OSA without CPAP and MO with OSA and CPAP. Methods/designĮPIMOOSA is a prospective non-interventional cohort study aiming to recruit 45 MO patients who are candidates for BS. We have thus initiated the Epigenetics modification in Morbid Obesity and Obstructive Sleep Apnoea (EPIMOOSA) study ( identifier: NCT03995836). The primary treatment of OSA is continuous positive airway pressure (CPAP), whereas bariatric surgery (BS) is the treatment of choice for MO. To date, circulating miRNA expression has been studied separately in both conditions, but never jointly. Recent studies suggest that circulating microRNA (miRNA) plays a potential role in the physiopathology of both conditions. Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m 2, are two closely related conditions. ![]()
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